GoldenBiotech Antroquinonol Phase 2 NSCLC Clinical Study Presents Brilliant Results in ASCO Meeting.

2019/05/17

Golden Biotechnology Corp.’s Antroquinonol Phase 2 NSCLC Clinical Study Presents Brilliant Results in ASCO Meeting Abstract.

ASCO Meeting Abstract :
Phase II multicenter study of antroquinonol in patients with stage IV non-small cell lung cancer who have failed at least two lines of anti-cancer therapy.

 
Meeting: 2019 ASCO Annual Meeting
Session Title: Lung Cancer—Non-Small Cell Metastatic: Publication Only
Track:Lung Cancer—Non-Small Cell Metastatic
Subtrack: Metastatic Non-Small Cell Lung Cancer
Abstract #: e20522
Clinical Trial Registry Number:NCT02047344
Citation:J Clin Oncol 37, 2019 (suppl; abstr e20522)

Authors:
Ching-Liang Ho, David S. Ettinger, Pei-Ni Chen, Howard Cheng, Wu-Che Wen, Shang-Yin Wu, Thierry Marie Jahan, Mary J. Fidler, Bradley Walter Lash, Igor I. Rybkin, Natalie Stanton; Division of Hematology and Oncology, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD; Golden Biotechnology Corporation, New Taipei City, Taiwan; Golden Biotechnology Corp., New Taipei City, Taiwan; Division of Hematology and Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; University of California San Francisco, San Francisco, CA; Rush University Medical Center, Chicago, IL; Guthrie Clinic, Sayre, PA; Henry Ford Cancer Institute, Detroit, MI; Arizona Clinical Research Center, Tucson, AZ

Background:The aim of this study was to assess the efficacy of Antroquinonol in patients with stage IV NSCLC after failure in two-lines of anti-cancer therapy.
Methods:
Patients with stage IV non-squamous NSCLC who have failed at 2-4 lines of anti-cancer therapy were eligible, though early stage or naïve patients may voluntarily participate. A maximum of 30 evaluable patients were to receive Antroquinonol 600mg per day, of which 15 patients were to be KRAS-positive and 15 patients KRAS negative. The primary endpoint of the study was progression-free survival from the start of treatment to week 12 with disease control rate and overall survival as key secondary endpoints.
Results:
There were 31 patients enrolled with evaluable population 30 patients, of which 15 patients were KRAS positive and 15 patients KRAS negative. 73% were with at least two prior chemotherapy. The median PFS of 7 patients with 2 prior chemotherapy was 22.9 weeks (95% confidence interval [CI]: 5.0, 31.1); and 11 patients with more than 2 prior chemotherapy was 11.9 weeks (95% confidence interval [CI]: 6.0, 14.1), with a 1-year PFS of 11.4%. Of 11 patients who had had more than 2 prior chemotherapy, the median OS was 47.3 weeks (95% CI: 14.1,-), with a 1-year OS of 39.3%, and the overall disease control rate was 72.7%, with 100% in KRAS negative and 50% in KRAS positive. No systemic toxicities were observed.
Conclusions:
The monotherapy of Antroquinonol brought up higher disease control rates and longer progression-free survival and overall survival, compared with historical data. Although KRAS negative shows much better than KRAS positive group, Antroquinonol still work well with KRAS positive patients. Clinical trial information: NCT02047344
https://meetinglibrary.asco.org/record/174289/abstract

Antroquinonol®

Antroquinonol® is the pure compound extracted from Antrodia camphorata. Antroquinonol® is patented by Golden Biotech and helps support the immune system.

We have finalized 10 new leading candidates for new drug development.

Antroquinonol® has applied for compound and use patents worldwide.